Dr. Mario, Nintendo’s great attempt to create a second handheld puzzle phenomenon after Tetris. What makes it especially distinctive is its medical virus-clearing theme, which gave Nintendo a puzzle identity entirely different from falling blocks and made it one of the system’s most recognisable early competitive puzzle games. For collectors, the UKV edition is also interesting because Dr. Mario went through multiple British print variants, making it a title where regional and print-run differences matter more than one might expect at first glance.